个人简介
刘红荣,湖南科技大学物理学本科,湘潭大学凝聚态物理博士,美国加州大学洛杉矶分校博士后,现任湖南师范大学二级教授,博士生导师,教育部长江学者特聘教授(2019年),第三批国家万人计划科技创新领军人才(2018年)。主要从事软物质与生物物理领域研究,在冷冻电镜病毒近原子分辨三维重构、病毒对称失配及非对称重构领域做出了系列原创性成果。
Email: hrliu@hunnu.edu.cn; hrliu2013@126.com
学术贡献
软物质与生物物理;冷冻电镜病毒结构解析
教学情况
X射线与电子显微学;光学;概率论与数理统计;计算物理;凝聚态物理前沿等
承担课题
1. 国家自然科学基金重点项目:冷冻电镜病毒非对称重构研究(12034006).
2. 国家自然科学基金面上项目:冷冻电镜噬菌体对称失配重构研究(32071209).
3. 湖南省自然科学基金创新研究群体项目:显微成像理论及生物应用(2019JJ1002).
4. 国家重点研发计划课题:冷冻电镜原子分辨结构解析高效算法的开发与应用(2016YFA0501103).
5. 国家自然科学基金重大研究计划(高性能科学计算的基础算法与可计算建模)集成项目:冷冻电镜三维重构的关键算法研究及其应用(91530321).
6. 国家自然科学基金面上项目:基于冷冻电镜二十面体对称失配三维重构的腺病毒结构研究(31570742).
7. 国家自然科学基金面上项目:双链RNA病毒甲基转移酶活性位点的空间定位—冷冻电镜原子分辨三维重构(31370736).
8. 国家自然科学基金重大研究计划项目(高性能科学计算的基础算法与可计算建模)培育项目:基于球坐标系的冷冻电镜二十面体病毒高分辨三维重构的算法研究(91230116).
9. 国家自然科学基金面上项目:最大熵方法在冷冻电镜单颗粒技术中的应用(31170706).
10. 国家自科基金面上项目:冷冻电镜单颗粒技术中测定生物大分子颗粒取向的新算法研究(31070663).
代表性论文
1. Shuai Yuan, Jialing Wang, Dongjie Zhu, Nan Wang, Qiang Gao, Wenyuan Chen, Hao Tang, Junzhi Wang*, Xinzheng Zhang*,Hongrong Liu*, Zihe Rao* and Xiangxi, Wang*, Cryo-EM structure of a Herpesvirus capsid at 3.1 Å, Science 2018, 360: eaao7283.
2. Hongrong Liu* and Lingpeng Cheng*, Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus, Science 2015, 349: 1347-1350.
3. Hongrong Liu, Lei Jin, Sok Boon S. Koh, Ivo Atanasov, Stan Schein, Lily Wu, Z Hong Zhou. Atomic structure of human adenovirus by cryoEM reveals interactions among protein networks, Science 2010, 329: 1038-1043.
4. Wenyuan Chen, Hao Xiao, Li Wang, Xurong Wang, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang, Zhonghua Liu, Jingdong Song*, Hongrong Liu*, and Lingpeng Cheng*, Structural changes in bacteriophage T7 upon receptor-induced genome ejection, Proc Natl Acad Sci USA 2021, 118: e2102003118.
5. Wenyuan Chen, Hao Xiao, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang,Li Wang, Jingdong Song*, Hongrong Liu*, Lingpeng Cheng*. Structural changes of a bacteriophage upon DNA packaging and maturation, Protein Cell 2020, 11(5):374–379.
6. Nan Wang#, Wenyuan Chen#, Ling Zhu#, Dongjie Zhu, Rui Feng, Jialing Wang, Bin Zhu, Xinzheng Zhang, Xiaoqing Chen, Xianjie Liu, Runbin Yan, Dongyao Ni, Grace Guoying Zhou, Hongrong Liu*, Zihe Rao*, Xiangxi Wang*. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Protein Cell 2020, 11(5):366–373.
7. Xiaowu Li, Li Wang, Xurong Wang, Wenyuan Chen, Tao Yang, Jingdong Song*, Hongrong Liu*, LingpengCheng*, Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis, J Mol Biol 2020, 432: 358-366.
8. Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang§, Jiawei Wang, Hongrong Liu*, Qin Fang*, Lingpeng Cheng*. Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proc Natl Acad Sci USA 2018, 115: 7344-7349.
9. Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*, and Lingpeng Cheng*. Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV, J Mol Biol 2017, 429: 79-87.
10. Xiaowu Li, Hongrong Liu*, Lingpeng Cheng. Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM, Bophys Rep 2016, 2: 25-32.
11. Bin Zhu, Chongwen Yang, Hongrong Liu*, Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, Ping Zhu,Identification of the Active Sites in the Methyltransferases of a Transcribing dsRNA Virus, J Mol Biol 2014, 426: 2167-2174.
12. Hongrong Liu, Lily Wu, Z Hong Zhou. Model of the trimeric fiber of human adenovirus 5 and its interactions with the pentameric penton base by cryo-electron microscopy, J Mol Biol 2011, 406: 764-774.
13. Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji, Lingpeng Cheng, Hongrong Liu*, Conserved fiber-penton base interaction revealed by a near-atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction, J Virol 2012, 86: 12322-12329.
14. Hongrong Liu, Lingpeng Cheng, Songjun Zeng, Canying Cai Z. Hong Zhou, Qibin Yang, Symmetry-adapted spherical harmonics method for high-resolution 3D single particle reconstructions, J. Strul Boil 2008, 161: 64-73.
获奖情况
1. 教育部长江学者特聘教授(2019)
2. 国家“万人计划”科技创新领军人才(2018)
3. 湖南省先进工作者(2020)
4. 第七届中国侨界贡献奖二等奖(2018)
5. 湖南师范大学利君育人先锋奖(2018)
6. 湖南省科技领军人才(2017)
7. 全省教育系统优秀共产党员(2016)
8. 科技部创新人才推进计划中青年科技创新领军人才(2017)
9. 国务院政府特殊津贴专家(2016)
10. 湖南省优秀科技工作者(2016)
11. 教育部新世纪优秀人才(2013)
12. 湖南省杰出青年基金获得者(2012)